TABLE 2.

Linear Regression Correlation Coefficients among CYP Enzyme Activities and AAIa Formation in Human Hepatic Microsomes^a

	pmol CYP per mg protein	Sudan I oxidation in presence of ketoconazole (CYP1A1)b	Phenacetin O-deethy-lation (CYP1A2)	Coumarin 7-hydroxylation (CYP2A6)	(S)-Mephenytoin N-demthy-lation (CYP2B6)	Paclitaxel 6α-hydroxy-lation (CYP2C8)	Diclofenac 4′-hydroxy-lation (CYP2C9)	(S)-Mephenytoin 4′-hydroxy-lation (CYP2C19)	Burfuralol 1′-hydroxy-lation (CYP2D6)	Chloroxazone 6-hydroxy-lation (CYP2E1)	Testosterone 6β-hydroxy-lation (CYP3A4)	Lauric acid 12-hydroxy-lation (CYP4A)
Correlation coefficient	0.307	0.884	0.932	0.268	−0.265	−0.119	0.067	0.215	−0.123	−0.030	−0.110	0.559
Significance	0.285	<0.0001	<0.0001	0.355	0.360	0.685	0.820	0.460	0.688	0.919	0.707	0.058

^aData calculated from Table 1.

^bCYP enzymes are shown in brackets.