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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: J Immunol. 2011 Dec 28;188(3):1394–1401. doi: 10.4049/jimmunol.1101018

Figure 7.

Figure 7

TLR9 expression in DCs is required and sufficient to induce LN hypertrophy. TLR9−/− DCs activated with L. major fail to induce LN hypertrophy. L. major infected DCs (5 × 105) from C57BL/6 (B6) or TLR9−/− mice, or uninfected DCs, were injected into the footpad of C57BL/6 mice, and the cellularity of the dLN assessed on day 3 (A). L. major infected DCs (1 × 106) from C57BL/6 (B6) or TLR9−/− mice, or uninfected DCs, were injected into the footpad of CD45.1 C57BL/6 mice, and the presence of the donor cells in the dLN assessed on day 3 (B). L. major infected DCs (1 × 106) from C57BL/6 (B6), or uninfected DCs, were injected into the footpad of C57BL/6 mice or TLR9−/− mice, and the cellularity of the dLN assessed on day 3 (C). The results expressed are the mean (+/− SE) number of cells in the dLN of 3 mice per group. The results are representative of 2 experiments.