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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: J Immunol. 2011 Dec 19;188(3):1206–1212. doi: 10.4049/jimmunol.1102773

Figure 4. SLAM co-stimulation promotes Th17 differentiation in memory CD4+ T cells.

Figure 4

(A)-(C) Memory (CD45RO+) CD4+ T cells were stimulated with anti-CD3 and co-stimulatory anti-CD28, anti-SLAMF3, SLAMF6 and control IgG under Th17 conditions for 7 days. IL-17 production was analyzed by intracellular staining. (A) Secretion of IL-17 by memory CD4+ T cells on day 7 was measured by ELISA. (B) shows percentages of IL-17 producing cells. The relative number of IL-17 producing cells is given as a percentage of memory CD4+ T cells. (C) One representative experiment is displayed (from day 7). (D) Kinetics of IL-17 secretion by memory CD4+ T cells in response to co-stimulation through SLAMF3, SLAMF6 and CD28. IL-17 levels were monitored on days 3 and 6 by ELISA.