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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: J Immunol. 2011 Dec 16;188(3):1381–1393. doi: 10.4049/jimmunol.1102359

Figure 4. IFN-γ is responsible for the increased arthritis severity in B6 IL-10−/− mice.

Figure 4

ELISA of serum IFN-γ at 2 weeks of infection in B6 and B6 IL-10−/− mice (N=5 mice per group (A). Arthritis was assessed in B6 and B6 IL-10−/− mice at 4 weeks of infection (N≥8 mice per group). B6 IL-10−/− mice were injected with PBS, control antibody, or α-IFN-γ over the course of infection. Ankle swelling was used to assess arthritis severity (B). Quantification of joint spirochetes at 4 weeks of infection, using qPCR (C). Statistical analyses were performed as reported in Materials and Methods.