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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: J Immunol. 2011 Dec 16;188(3):1381–1393. doi: 10.4049/jimmunol.1102359

Figure 6. Ankle infiltration by multiple immune cells is regulated by IL-10 in infected B6 mice, and is partially dependent on IFN-γ.

Figure 6

Flow cytometry analysis of joint single cell suspensions in B6 and B6 IL-10−/− mice. Data in A and B were acquired from six pooled joints from 3 B6 and 3 B6 IL-10−/− mice. Frequency of NK cells, NKT cells, α/β T cells in uninfected B6 (A-i), uninfected B6 IL-10−/− (A-ii), 2 week infected B6 (A-iii) and 2 week infected B6 IL-10−/− (A-iv) ankle joints. Frequency of macrophages in uninfected B6 (B-i), uninfected B6 IL-10−/− (B-ii), 2 week infected B6 (B-iii), 2 week infected B6 IL-10−/− (B-iv) ankle joints. Infiltration of NK cells (C), NKT cells (D), α/β T cells (E) and macrophages (F) in joint tissue at 14 days of infection in B6 and B6 IL-10−/− mice injected with PBS, isotype control antibody, or α-IFN-γ. N≥3 for each group. Statistical analysis was performed as described in Materials and Methods.