Table II.
Assessment of Arthritis by Histopathology in B. burgdorferi-infected Joints.a
| Infected Mouse Strain |
Antibody Treatment |
Overall Lesionb |
Neutrophil Infiltrationb |
Mononuclear Infiltrationb |
Sheath Thickeningb |
|---|---|---|---|---|---|
| B6 IL-10−/− | PBS (none) | 2.88±1.00 | 2.38±0.46 | 1.00±0.19 | 2.38±0.32 |
| B6 IL-10−/− | Isotype | 2.55±0.77 | 1.91±0.34 | 1.27±0.30 | 2.27±0.24 |
| B6 IL-10−/− | α-IFN-γ | 1.50±0.43** | 1.17±0.27 | 0.33±0.19** | 1.08±0.23** |
a
Assessed at 4 weeks of infection, as described in Materials and Methods
b
Values represent mean ± S.E.M.
Statistical significance between α-IFN-γ and Isotype is indicated by (**). p<0.01 by Mann Whitney U test