A. In absence of p300-mediated acetylation, β-catenin interacts with DNA binding proteins of the TCF/LEF families, activating gene expression via TCF/LEF promoter elements. This results in a pro-proliferative transcriptional profile.
B. Acetylation of β-catenin C-terminal domain promotes direct interaction between β-catenin and VDR on VDREs in vitamin D-responsive gene promoters. This leads to an anti-proliferative gene expression profile.