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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Rev Endocr Metab Disord. 2012 Mar;13(1):31–38. doi: 10.1007/s11154-011-9196-y

Figure 1. Schematic of p300-mediated acetylation of β-catenin differentiates between TCF- and VDR-dependent gene activation.

Figure 1

A. In absence of p300-mediated acetylation, β-catenin interacts with DNA binding proteins of the TCF/LEF families, activating gene expression via TCF/LEF promoter elements. This results in a pro-proliferative transcriptional profile.

B. Acetylation of β-catenin C-terminal domain promotes direct interaction between β-catenin and VDR on VDREs in vitamin D-responsive gene promoters. This leads to an anti-proliferative gene expression profile.