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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Inflamm Bowel Dis. 2012 Feb;18(2):323–332. doi: 10.1002/ibd.21779

FIGURE 2.

FIGURE 2

Deletion of PSGL-1 attenuates DSS-induced colitis. (A) Mice were sacrificed at baseline, on day 7 after 6 days of DSS treatment, and on day 14. Colons were stained with H&E to assess histologic colitis. A robust infiltration of leukocytes was seen in WT mice resulting in progressive expansion of the mucosa, submucosa, and muscular thickening from day 7 to day 14. Submucosal infiltration was diminished, and often absent by day 14, in PSGL-1−/− mice despite evidence of DSS-induced mucosal injury. (B) Colon lengths measured from the cecum to anus. (C) Histologic colitis scores. (n = 3–4 per group). *, p < 0.05; #, p < 0.01 vs. WT, same day. Data are mean ± SEM.