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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: J Neuroendocrinol. 2012 Apr;24(4):528–538. doi: 10.1111/j.1365-2826.2011.02236.x

Figure 3.

Figure 3

Summary of results from Transgenic and Organotypic Culture/Biolistics Studies (1987–2003). These constructs were found to produce cell-type specific expression in the Oxt and Avp MCNs in the SON. In transgenic rodents the Avp gene with 3.5kbp upstream and 2.1kbp downstream (dotted line) of the gene body produced cell-type specific expression, whereas using biolistics and organotypic culture only 288bp upstream and 178bp downstream were found to be neccessary. For the Oxt gene 568bp upstream and 3.6kbp downstream of the gene body in the transgene produced cell-type specific expression, whereas in biolistic experiments 568bp upstream and only 432bp downstream were found to be sufficient (see reviews by Young and Gainer, (10); and Murphy and Wells(11)).