Table 3.

ADMET profile for compound 18.

Parameter	Value
Aqueous solubility (PBS, pH 7.4) at 2.0 × 10−4 m:	31.8 ± 1.8 μm
Protein bound (human):	82.8 ± 11.1 %
Protein recovery (human):	95.6 ± 13.6 %
A–B permeability (TC7, pH 6.5/7.4) [10−6 cm s−1]:	52.2 ± 1.7
A–B permeability (% recovery):	63.5 ± 6.5 %
B–A permeability (TC7, pH 6.5/7.4) [10−6 cm s−1]:	16.2 ± 0.2
B–A permeability (% recovery):	85.5 ± 0.5 %
Ames test (strain TA98):	<0
Ames test (strain TA98 +S9):	<0
K+ channel hERG automated patch-clamp (cardiac toxicity):	inactive at 1 μm