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. 2012 Jan 4;32(1):124–132. doi: 10.1523/JNEUROSCI.3442-11.2012

Figure 1.

Figure 1.

SIRT1 prolongs the life span of homozygous A53T mouse model—mice expressing α-synuclein gene with A53T mutation. A, Survival analysis of A53T and A53T mice overexpressing SIRT1 (A53T-Tg). n = 32 for each genotype. B, Survival analysis of A53T and A53T mice lacking SIRT1 in brain (A53T-BSKO). n = 24 for each genotype. Graphs show percentage of survival scored monthly. C, A53T α-synuclein RNA levels quantified from whole brains of A53T and A53T-Tg or A53T-F/F and A53T-BSKO mice by qPCR. n = 4 for each indicated genotype. D, Western blotting of SIRT1 in whole-brain extracts from A53T mice and wt littermates. n = 6 for each genotype. Quantification is shown on the right. A representative blot is shown. The statistical analysis in C and D was performed using Student's t test. Error bars in figures represent SEM.