Table 5.
Combination Effect of BRCA1 Genotypes
| |
Controls (No.=511) |
DTC cases (No.=303) |
|
PTC cases (No.=273) |
|
|||
|---|---|---|---|---|---|---|---|---|
| No. of favorable genotypes | No. | (%) | No. | (%) | Adjusted ORa(95% CI) | No. | (%) | Adjusted ORa(95% CI) |
| 0 | 177 | (34.6) | 126 | (41.6) | 1.00 | 112 | (41.0) | 1.00 |
| 1–2 | 52 | (10.2) | 29 | (9.6) | 0.64 (0.36–1.11) | 25 | (9.2) | 0.62 (0.34–1.12) |
| 3–4 | 282 | (55.2) | 148 | (48.8) | 0.69 (0.50–0.95) | 136 | (49.8) | 0.70 (0.50–0.98) |
| ptrend=0.028 | ptrend=0.046 | |||||||
a
Adjusted for age, sex, ethnicity, first-degree family history of thyroid cancer, smoking status, and radiation exposure.