Table 4.

Collagenase induced changes in the transfer constants of the contrast agent at the central region of H460 tumors

Vascular and transport parameters	Before collagenase Mean of median ± SD	After collagenase Mean of median ± SD	value*
p Pressure gradient-dependent transfer constant, ±kΔp, min−1	(2.1±9.4) ×10−3	(6.7 ±9.0)× 10−3	0.006
Concentration gradient- dependent transfer constant, ktrans, min−1	(7.1±5.7)×10−3	(4.7 ±4.5)×10−3	0.27
Intravascular volume fraction, νp	0.029 ±0.015	0.034 ± 0.017	0.51

^*paired t-test (n=12)