Table 2.

The Median Values, Lower and Upper Quartiles of Fibrosis Biomarkers in the Study Groups

Variable	Healthy Control N = 279	Control N = 280	HFPEF N = 175	HFREF N = 146	p-value*
PIP (μg/l)	403 (336, 491)	384 (321, 467)	395 (329, 503)	406 (353, 477)	0.25
CITP (μg/l)	3.8 ( 2.8, 5.3)	4.5 (3.2, 5.9)	5.9 (4.3, 8.6)	5.7 (4.0, 8.3)	<0.0001
PIIINP (ng/ml)	3.1 (2.4, 4.0)	3.8 (2.8, 5.0)	4.2 (3.0, 6.9)	4.7 (3.4, 7.2)	<0.0001

^*p-values for pair comparisons of CITP and PIIINP < 0.0001 for all the groups with the exception of HF groups in which were not significant ( CITP =0.55 and PIIINP = 0.24)