Table 1.
Histopathologic and clinical characteristics of Spitzoid Malignant Melanoma cases
| Case No. | Age | Gender | Site | Depth (mm) | Clark’s Level | Ulceration/Regression | Mitoses /mm2 | Follow-up (years) | Adverse event(s) | MS Results (tumor) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 72 | F | Leg, lower | 4 | IV | No/Yes | <1 | 1 | DOD; satellitosis, 0/1 SLN | NA |
| 2 | 75 | M | Arm, upper | 1.3 | IV | No/Yes | 2 | 5 | Alive-NED; 0/5 SLN | NA |
| 3 | 54 | M | Back | 1.2 | IV | No/Yes | 2 | 5 | Alive-NED; 0/6 SLN | NA |
| 4 | 64 | F | Knee | 3.8 | IV | No/No | <1 | 3 | Alive-NED; 0/3 SLN | NA |
| 5 | 52 | F | Leg | 1.2 | IV | No/No | 2 | 5 | Alive-NFA | NA |
| 6 | 78 | F | Back | 3.5 | IV | Yes/No | 17 | 4 | Alive-NED | NA |
| 7 | 74 | M | Back | 3 | IV | Yes/No | 6 | 4 | Alive-NED; 0/1 SLN | NA |
| 8 | 48 | F | Leg, lower | 1.3 | IV | No/No | 1 | 4 | Alive-NED;0/2 SLN | NA |
| 9 | 38 | F | Thigh | 1.9 | IV | Yes/No | 26 | 3 | Alive-NED; 1/2 SLN;0/8 CLD | NA |
| 10 | 72 | M | Arm | 5.5 | IV | No/no | 5 | 3 | Alive w/d-multiple brain mets; 0/1 SLN | NA |
| 11 | 76 | F | Leg | 3.1 | IV | Yes/No | 2 | 3 | Alive-NED; 0/2 SLN | NA |
| 12 | 86 | M | Chest | 4.8 | IV | Yes/No | 2 | 3 | Alive-NED; 0/6 SLN | NA |
| 13 | 60 | M | Arm | 5 | IV | No/No | 4 | 2 | Alive w/d-multiple liver, brain, lung mets; 0/19 CLD | NA |
| 14 | 67 | M | Leg | 8 | V | Yes/No | 8 | 1 | DOD; brain and lung mets | NA |
| 15 | 56 | M | Ear | 2.3 | IV | No/No | 2 | 2 | Alive-NED; 0/3 SLN | NA |
| 16 | 88 | F | Leg | 2.5 | IV | No/No | 3 | 4 | NFA | NA |
| 17 | 78 | F | Scalp | 2.9 | IV | No/No | 5 | 2 | Alive-NED; 0/4 SLN | NA |
| 18 | 70 | M | Back | 3.4 | IV | No/No | 2 | 3 | Alive-NED; 1/4 SLN; 0/37 CLD | NA |
| 19 | 50 | M | Back | 3.2 | IV | No/No | 12 | 2 | Alive-NED; 0/2 SLN | NA |
| 20 | 57 | M | Arm | 3.4 | IV | No/No | 3 | 2 | Alive-NED; 0/2 SLN | NA |
| 21 | 53 | M | Leg | 1.9 | IV | No/No | 8 | 2 | Alive-NED; 0/2 SLN | NA |
| 22 | 62 | M | Leg, lower | 2.3 | IV | No/No | 2 | 2 | Alive-NED; 0/3 SLN | NA |
| 23 | 58 | M | Thigh | 2.1 | IV | No/No | 3 | 2 | Alive-NED; 1/3 SLN; 0/11 CLD | NA |
| 24 | 45 | F | Back | 2 | IV | No/No | <1 | 2 | Alive-NED; 1/6 SLN;0/14 CLD | NA |
| 25 | 88 | M | Ear | 3 | IV | No/No | 2 | 2 | Alive-NED | NA |
| 26 | 64 | M | Leg | 7.5 | IV | No/No | 2 | 1 | Alive-NED; 1/4 SLN | + |
| 27 | 43 | M | Temple | 3.8 | IV | Yes/No | 10 | 14 | Alive-NED; 0/2 SLN; 1/29 CLD | + |
| 28 | 60 | M | Arm | 3.5 | IV | No/No | <1 | 4 | Alive-NED; 0/1 SLN | + |
| 29 | 44 | F | Leg | 0.75 | IV | No/No | 1 | 3 | Alive-NFA | + |
| 30 | 52 | F | Arm | 2.2 | IV | Yes/No | 4 | 3 | Alive-NED | + |
| 31 | 65 | F | Back | 1.1 | IV | No/No | <1 | 2 | Alive-NED | + |
| 32 | 51 | F | Leg | 0.9 | IV | No/No | <1 | 2 | Alive-NED; 0/4 SLN | + |
| 33 | 89 | F | Arm | 3 | IV | No/No | 4 | 2 | NFA | + |
| 34 | 58 | M | Back | 1.1 | III | No/No | 5 | 2 | Alive-NED; 0/2 SLN | + |
| 35 | 57 | F | Arm | 0.95 | IV | Yes/Yes | 2 | 4 | Alive-NED; 0/2 SLN | + |
| 36 | 46 | F | Arm | 1.3 | IV | No/No | 2 | 3 | Alive-NED | + |
| 37 | 52 | F | Abdomen | 13 | IV | Yes/No | 6 | 2 | Alive w/d - local recurrence, multiple brain and subcutaneous mets; 0/6 SLN; 1/19 CLD | + |
| 38 | 75 | M | Scalp | 2.1 | IV | No/No | 2 | 3 | DOD-satellitosis, multiple mets; 0/1 SLN | + |
| 39 | 59 | M | Leg | 2 | IV | No/No | <1 | 7 | Alive-NED; 0/7 SLN | + |
| 40 | 62 | M | Arm | 4.5 | IV | No/No | <1 | 7 | Alive-NED; 1/4 SLN and 0/5 CLD | + |
| 41 | 86 | M | Leg, lower | 5 | IV | No/No | 4 | 4 | DOD-local recurrence and multiple mets | + |
| 42 | 58 | F | Knee | 6 | IV | Yes/No | 6 | 2 | Alive-NED | + |
| 43 | 29 | M | Back | 2.5 | IV | Yes/No | 2 | 1 | Alive-NED; 0/2 SLN; 5/10 CLD | + |
| 44 | 50 | F | Thigh | 4.8 | IV | No/No | <1 | 1 | Alive-NED; 1/3 SLN; 0/4 CLD | − |
| 45 | 76 | M | Back | 2.1 | IV | Yes/No | 6 | 1 | Alive-NED; 0/4 SLN | + |
| 46 | 57 | M | Back | 4.8 | IV | Yes/No | 10 | 1 | NFA | + |
| 47 | 87 | F | Arm | 2.3 | IV | Yes/No | 18 | 1 | NFA | + |
| 48 | 38 | M | Chest | 8 | IV | Yes/No | 1 | 21 | Alive; R axilla-1/18 CLD; L axilla-4/15 CLD | + |
| 49 | 61 | M | Leg, lower | 2 | IV | Yes/No | 5 | 20 | Alive w/d; satellitosis, multiple mets; 2/25 CLD | − |
| 50 | 75 | M | Scalp | 2.1 | IV | No/Yes | <1 | 3 | DOD-satellitosis, local recurrence, multiple mets | − |
| 51 | 59 | M | Back | 2.9 | IV | No/No | <1 | 14 | Alive w/d; soft tissue mets; 0/12 CLD | + |
| 52 | 79 | F | Cheek | 9 | V | Yes/No | 2 | 2 | Alive-NFA | + |
| 53 | 69 | M | Back | 1.8 | IV | No/No | 17 | 2 | Alive-NED; 1/2 SLN in R axilla; 3/10 SLN in L axilla; 0/19 CLD | + |
| 54 | 51 | M | Knee | 1 | III | No/No | <1 | 2 | Alive-NFA | + |
| 55 | 53 | F | Leg | 1 | IV | No/No | 1 | 2 | Alive-NED; 0/2 SLN | ++ |
| 56 | 48 | F | Thigh | 0.8 | III | Yes/No | <1 | 8 | DOD; multiple mets | ++ |
| 57 | 62 | F | Scalp | 3.5 | IV | No/No | <1 | 2 | DOD-multiple mets; 1/11 CLD | ++ |
| 58 | 63 | F | Leg | 5.5 | IV | Yes/No | 5 | 2 | Alive-NED; 0/3 SLN | ++ |
DOD-died of disease; NED-no evidence of disease; SLN-sentinel lymph node(s); CLD-completion lymphadenectomy; mets-metastases; w/d – with disease; LN-lymph nodes; NA-Not applicable; NFA-no follow up available; ++ - correct recognition based on dermis only (no tumor available); Cases 1–25 are part of the teaching set, cases 26–58 are part of the validation set.