Figure 1. Average effect size estimates and corresponding 95% confidence intervals of the acute treatment efficacy of cognitive-behavioral therapy as compared with placebo on the various anxiety disorders for the primary continuous anxiety measure (dark blue bars) and depression measures (light blue bars) Adapted from ref 6: Hofmann SG, Smits JA. Cognitive-behavioral therapy for adult anxiety disorders: a meta-analysis of randomized placebo-controlled trials. J Clin Psychiatry. 2008;69:621-632. Copyright© Physicians' Postgraduate Press, 2008 .