Table 6.
Cytotoxicities of various curcumin to Hela and HT-29 cells
| Treatment group (Hela) | IC50 (μM)a | Treatment group (HT-29) | IC50 (μM)a |
|---|---|---|---|
| CUR-FSMEDDS | 18.27 ± 1.13 | CUR-FSMEDDS | 20.57 ± 0.78 |
| CUR-FSMEDDS + 1 mM folate | 27.27 ± 1.56 | CUR-FSMEDDS + 1 mM folate | 30.31 ± 2.71 |
| CUR-SMEDDS | 36.69 ± 1.04 | CUR-SMEDDS | 38.59 ± 0.17 |
| Free curcumin | 30.4 ± 1.71 | Free CUR | 25.62 ± 2.23 |
a
Note: Data presented as mean value ± standard error, n = 3.
Abbreviations: CUR-FSMEDDS, curcumin-loaded folate-modified self-microemulsifying drug delivery system; CUR-SMEDDS, curcumin-loaded self-microemulsifying drug delivery system; IC50, 50% cell killing; Hela cells, human uterine cervix cancer cell line; HT-29 cells, human colon carcinoma cell line.