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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Brain Res Bull. 2011 Aug 10;88(1):58–71. doi: 10.1016/j.brainresbull.2011.08.005

Fig. 4. Schematic illustrating key subdomains within neurofibromin, the tumor suppressor protein encoded by the NF1 gene.

Fig. 4

Subdomains are indicated as follows: CSRD, cysteine/serine-rich domain; TBD, tubulin-binding domain; GRD, GAP-related domain; Sec14/PH, Sec14-homologous domain and pleckstrin homology domain; NLS, nuclear localization sequence. Numbers above each subdomain indicate the positions of the corresponding amino acids within the 2818 amino acid length of the neurofibromin protein. The amino acid position of the TBD is not indicated, as this is an 80 amino acid region found within the N-terminal GRD domain.