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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Brain Res Bull. 2011 Aug 10;88(1):58–71. doi: 10.1016/j.brainresbull.2011.08.005

Fig. 5. Schematic illustrating established and potential interactions between NF1−/− Schwann cells and other NF1 haploinsufficient cell types intrinsic to peripheral nerve.

Fig. 5

Established interactions are depicted with solid black arrows and font, while potential interactions are depicted with gray dashed arrows labeled with question marks. Established interactions include the elevated secretion of Kit ligand from NF1+/− Schwann cells, which is further increased upon loss of the remaining NF1 allele and which acts as a chemoattractant and activating factor for NF1+/− mast cells. Activated NF1+/− mast cells have also been shown to secrete elevated levels of TGFβ, which stimulates increased collagen deposition from NF1+/− fibroblasts.