Table 5.
Antibacterial activity of avarone, its derivatives, lysozyme and its conjugates with various derivatives of avarone towards Gram-positive bacteria (in parentheses are the MIC of the conjugates expressed as quinone concentration)
| MIC (μM) | ||||||
|---|---|---|---|---|---|---|
| Compound | S. lutea | S. aureus | M. flavus |
S. longisporum |
C. sporogenes |
B.subtilis |
| I | 20.03 | 40.06 | 20.03 | 20.03 | 20.03 | 80.13 |
| Ia | 36.55 | 36.55 | 36.55 | 36.55 | 18.27 | 36.55 |
| Ib | - | - | - | - | - | - |
| Ic | 469.21 | 3812.32 | 3812.32 | 3812.32 | 3812.32 | 967.74 |
| I-L | 168.23 (3.59) |
5.47 (0.12) |
168.23 (3.59) |
168.23 (3.59) |
336.46 (7.18) |
168.23 (3.59) |
| Ia-L | 95.54 (2.23) |
3.07 (0.07) |
191.09 (4.46) |
191.09 (4.46) |
191.09 (4.46) |
191.09 (4.46) |
| Ib-L | 102.38 (2.38) |
1.71 (0.04) |
402.68 (9.37) |
204.75 (4.77) |
204.75 (4.77) |
204.75 (4.77) |
| Ic-L | 95.55 (2.22) |
1.54 (0.04) |
395.85 (9.21) |
197.92 (4.61) |
197.92 (4.61) |
197.92 (4.61) |
| Treated-L | 223.57 | 27.94 | 111.79 | 447.15 | 223.57 | 111.79 |
| Lysozyme | 202.61 | 12.58 | 405.23 | 405.23 | 817.44 | 202.61 |
| Amikacin | 3.42 | 18.78 | 3.42 | 111.00 | 25.61 | 71.72 |