Table 6.
Antibacterial activity of avarone, its derivatives, lysozyme and its conjugates with various derivatives of avarone towards Gram-negative bacteria (in parentheses are the MIC of the conjugates expressed as quinone concentration)
| MIC (μM) | ||||
|---|---|---|---|---|
| Compound | E. coli | P. vulgaris | P. aeruginosa | S. enteritidis |
| I | 440.96 | 27.56 | 13.78 | 55.12 |
| Ia | 877.20 | 109.65 | 438.60 | 877.20 |
| Ib | - | - | - | - |
| Ic | - | - | - | - |
| I-L | 11.11 (0.24) |
22.22 (0.47) |
88.88 (1.90) |
11.11 (0.24) |
| Ia-L | 266.16 (6.21) |
2.14 (0.05) |
266.16 (6.21) |
68.25 (1.59) |
| Ib-L | 81.90 (1.91) |
156.98 (3.65) |
122.85 (2.86) |
307.13 (7.15) |
| Ic-L | 5.12 (0.12) |
10.24 (0.24) |
20.48 (0.48) |
40.96 (0.95) |
| Treated-L | 27.94 | 27.94 | 223.57 | 223.57 |
| Lysozyme | >740.58 | >740.58 | 188.64 | 370.29 |
| Amikacin | 8.54 | 11.95 | 85.38 | 13.66 |