Fig. (3).

The variable affinity of phylogenetically diverse sHsps for tau may be therapeutically relevant. Client specificity of sHsps is not well characterized. Small Hsp-mediated prevention of toxic tangle formation can be further enhanced by selecting sHsps, perhaps even from other species, with higher affinity for tau and driving their expression. Therefore certain sHsps will likely bind tau quicker and more stably, intervening before tau can begin to aggregate.