Fig. (3).

AD and FTD Pathologies. Representative gross photographs (A-C) and photomicrographs (D-G) demonstrate features of Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Gross photographs of coronal slices of human brain at the level of the lateral geniculate nucleus show that AD brains can have extreme atrophy of the hippocampal formation (red arrows in A,B). A slightly more anterior slice from an FTD patient (C) depicts the atrophy in the region of the temporal pole (black arrowhead). Silver stains show both neuritic plaques (D) and neurofibrillary tangles (E) in AD. Immunohistochemistry is useful to stain disease-related antigens: Aβ peptide at low magnification in AD neocortex (F), and modified tau protein (“Pick bodies”) in the dentate granule cells in Pick’s disease, a subtype of FTD (G). Scale bars for photomicrographs: 20 μm in D,E; 1 mm in F, and 50 µm in G.