Figure 1.

Summary of the stem cells niche location in skin and hair follicle and their p63 isoforms expression. ΔNp63 is expressed in the basal layer of the epidermis, known as stem cell niches for keratinocytes and melanocytes, as well as in the hair follicle (HF)-bulge area, where hair follicle stem cells (HFSC)/K15+cells, Nestin+/K15− cells and epidermal-neural crest stem cells (Epi-NCSC) reside. TAp63 is expressed in the HF dermal stem cells and in the HF bulge area. Whether or not each of the stem cells localized in the HF-bulge area expresses p63 isoform still remains to be investigated. DP, dermal papilla; DS, dermal sheath; IRS, inner root sheath; ORS, outer root sheath; SKPs, skin-derived precursors; TA cells, transient amplifying cells