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. 2011 Jul 1;19(2):209–219. doi: 10.1038/cdd.2011.84

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Copyright © 2012 Macmillan Publishers Limited

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Persistent overexpression of Jagged2 inhibits OLP generation. Embryos EP at HH18 with Jagged2 (GOF-JAG2), or control empty vector (Control), were analysed at 4, 5 days after EP for oligodendrocyte generation. (a and c) Oligodendrocytes are identified as migratory cells departing from the pMN expressing Olig2 (red) and Nkx2.2 (green). Electroporated side is shown to the right, GFP (blue) shows transfected cells. Controls show numerous migratory OLPs. GOF-JAG inhibits OLP migration. (b and d) Oligodendrocytes are identified as migratory expressing Olig2 (red) and O4 (green). Electroporated side is shown to the right, GFP (blue) shows transfected cells. Controls show numerous migratory OLPs. GOF-JAG inhibits OLP migration. (e) Quantitative analysis of Olig2+ migratory cells at 72 h and 108 h after electroporation of the indicated DNAs. Numbers are shown as migratory marker expressing cell in each experimental condition. Bars correspond to the standard error (S.E.M.)