Figure 6.

 VDAC1 selectively transfers apoptotic Ca²⁺ signals to mitochondria. Representative traces (a) and statistics (b) of [Ca²⁺]_mt evoked by the acute administration of 1 mM H₂O₂ ([Ca²⁺]_mt peak values: control, 0.617±0.015 μM; siRNA-hVDAC1, 0.469±0.025 μM; siRNA-hVDAC2, 0.632±0.016 μM; siRNA-hVDAC3, 0.644±0.016 μM). (c) [Ca²⁺]_mt increases evoked by 0.5 μM histamine. All other conditions as in Figure 2