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. Author manuscript; available in PMC: 2012 Jan 23.

Published in final edited form as: Am J Med. 2009 Dec;122(12):1142–1149.e1-2. doi: 10.1016/j.amjmed.2009.02.021

Association between higher Drug Burden Index (DBI) at years 1, 3 and 5, and total drug burden exposure over five years, calculated using area under the drug burden time curve (AUCDB), with lower functional scores at year 6 measured with SPPB score (A), usual gait speed in m/s (B) or grip strength in kg (C).

DBI and AUCDB grouped into 0, 0-1 and ≥ 1. Means adjusted for year 1 functional score, co-morbidities, hospitalizations and sociodemographic factors using analysis of co-variance.

Error bars show 95% confidence intervals. * indicates that the difference between bars linked by brackets is statistically significant, p<0.05. Number of subjects at each level of exposure at each time point is shown in table below each figure.

Association between higher Drug Burden Index (DBI) at years 1, 3 and 5, and total drug burden exposure over five years, calculated using area under the drug burden time curve (AUCDB), with lower functional scores at year 6 measured with SPPB score (A), usual gait speed in m/s (B) or grip strength in kg (C).

DBI and AUCDB grouped into 0, 0-1 and ≥ 1. Means adjusted for year 1 functional score, co-morbidities, hospitalizations and sociodemographic factors using analysis of co-variance.

Error bars show 95% confidence intervals. * indicates that the difference between bars linked by brackets is statistically significant, p<0.05. Number of subjects at each level of exposure at each time point is shown in table below each figure.