Table 3.

Multiple regression analyses for association of exposure to drug burden at year 1 (3a) and the area under the curve for drug burden (AUCDB) from years 1 and 6 (3b), with physical function at year 6 (SPPB Score, Gait Speed (m/s) and Grip Strength (kg)). The parameter estimates, B, tell the amount of change in each functional score that would be predicted by a 1 unit change in the predictor. The t Value and Pr > |t| columns provide the t-value and 2 tailed p-value used in testing the null hypothesis that the parameter estimate is 0. R-Square is the proportion of variance in the functional score which can be predicted from the independent variables. FCI; functional comorbidity index.

Table 3a. Multiple regression for association of Drug Burden Index at baseline (year 1) with functional measures at year 6.
	Functional Measure at Year 6
	Short Physical Performance Battery Score			Usual Gait Speed (m/s)			Grip Strength (kg)
Factor	B	T	Pr> ItI	B	T	Pr> ItI	B	T	Pr> ItI
Age	−0.09	−6.34	<0.0001	−0.01	−6.29	<0.0001	−0.25	−5.89	<0.0001
Sex (Female)	−0.30	−3.52	=0.0004	−0.05	−5.10	<0.0001	−4.20	−11.39	<0.0001
Race (Black)	−0.31	−3.38	=0.0007	−0.05	−4.68	<0.0001	−0.13	−0.49	ns
Study Site (Memphis)	0.01	0.17	ns	0.02	1.63	ns	−0.14	−0.58	ns
Secondary Education (Absent)	−0.11	−1.01	ns	−0.03	−2.62	=0.009	0.75	2.43	<0.05
Baseline FCI	−0.10	−3.55	=0.0004	−0.01	−4.54	<0.0001	0.05	0.64	ns
Additional comorbidities over 6 years	−0.15	−2.65	=0.008	−0.01	−2.06	=0.04	−0.33	−1.98	<0.05
Hospitalization years 1-6	−0.32	−3.79	=0.0002	−0.03	−3.21	=0.001	−0.94	−3.85	=0.0001
Cumulative Anxiety, Depression, Cognitive Impairment	−0.26	−4.74	<0.0001	−0.02	−3.79	=0.0002	−0.55	−3.48	=0.0005
Cumulative Sleep Problems	−0.01	−0.13	ns	−0.01	−0.81	ns	−0.04	−0.14	ns
Baseline Functional Measure	0.63	21.47	<0.0001	0.51	22.31	<0.0001	0.64	37.48	<0.0001
Baseline Drug Burden Index	−0.29	−2.67	=0.008	−0.04	−3.26	=0.001	−0.56	−1.76	=0.08
Adjusted R2	0.31			0.37			0.73

Table 3B. Multiple regression for association of the area under the Drug Burden Index - time curve (AUCDB) over five years with functional measures at year 6.
	Functional Measure at Year 6
	Short Physical Performance Battery Score			Usual Gait Speed (m/s)			Grip Strength (kg)
Factor	B	T	Pr> ItI	B	T	Pr> ItI	B	T	Pr> ItI
Age	−0.09	−6.30	<0.0001	−0.01	−6.22	<0.0001	−0.25	−5.91	<0.0001
Sex (Female)	−0.31	−3.63	=0.0003	−0.05	−5.21	<0.0001	−4.26	−11.53	<0.0001
Race (Black)	−0.31	−3.40	=0.0007	−0.05	−4.69	<0.0001	−0.15	−0.56	ns
Study Site (Memphis)	0.02	0.21	ns	0.02	1.66	ns	−0.10	−0.56	ns
Secondary Education (Absent)	−0.11	−1.05	ns	−0.03	−2.64	=0.008	0.73	2.38	=0.02
FCI at baseline	−0.10	−3.54	=0.0004	−0.01	−4.55	<0.0001	0.07	0.82	ns
Additional comorbidities over 6 years	−0.15	−2.62	=0.009	−0.01	−2.03	=0.04	−0.33	−1.97	<0.05
Hospitalization years 1-6	−0.31	−3.76	=0.0002	−0.03	−3.19	=0.002	−0.92	−3.78	<0.0005
Cumulative Anxiety, Depression, Cognitive Impairment	−0.25	−4.67	<0.0001	−0.02	−3.73	=0.0002	−0.52	−3.31	=0.001
Cumulative Sleep Problems	−0.01	−0.10	ns	−0.01	−0.79	ns	−0.01	−0.04	ns
Baseline Functional Measure	0.63	21.69	<0.0001	0.51	22.26	<0.0001	0.64	37.51	<0.0001
AUCDB	−0.08	−2.46	=0.01	−0.01	−2.86	=0.004	−0.27	−2.87	=0.004
Adjusted R2	0.30			0.37			0.73