Table 2.
Promoter hypermethylation and expression in cell lines.
| Cell line | Diagnosis | Methylation | Expression | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| PTEN | MGMT | RASSF1A | p14 | p16 | PTEN | MGMT | RASSF1A | p14 | p16 | ||
| T98G | GBM | − | ■ | ■ | − | * | + | + | − | − | − |
| LN-405 | GBM | − | ■ | □ | − | − | + | − | −/+ | + | + |
| U118 | GBM | − | ■ | ■ | * | * | § | § | § | § | § |
| U251 | GBM | − | ■ | ■ | * | * | § | § | § | § | § |
| U87 | GBM | − | ■ | ■ | * | * | + | − | − | − | − |
| MOG-G-CCM | AIII | □ | ■ | ■ | − | * | + | + | − | + | + |
| SW1088 | AIII | − | ■ | □ | * | * | − | − | −/+ | − | − |
| SW1783 | AIII | − | − | ■ | − | − | + | + | − | + | + |
| GOS3 | A/O (II/III) | □ | − | ■ | * | − | + | − | − | − | − |
GBM: glioblastoma multiforme; AIII: anaplastic astrocytoma; A/O: astrocytoma/oligodendroglioma. ■: methylated; □: hemimethylated; +: expression; −/+: low expression; −: lack of expression/absence of methylation; *: nonanalyzed; §: nonstudied.