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. 2011 Dec 18;2011:965826. doi: 10.1155/2011/965826

Figure 2.

Figure 2

Pharmacokinetics of oral TAC versus i.v. 5-azacitidine in C57BL/6 mice. (a) Mean plasma concentration versus time for tri-acetyl azacytidine (TAC) (▲) and resultant ACT (●) in nontumor bearing mice after a 38 mg/kg dose of oral TAC. Mean plasma concentration versus time for ACT in nontumor bearing mice after 25 mg/kg ACT i.v. (°). Error bars indicate standard deviation. (b) Noncompartmental plasma pharmacokinetic parameters for azacitidine (ACT) and tri-acetyl azacitidine (TAC). AUClast values are mean (standard error). NE—not estimated. NC—not calculated.