Table 1.

Stability of TAC and its metabolites at various pH.

Sample	TAC (%)	DAC (%)	MAC (%)	ACT (%)
Control	100
pH 1—1 hr	99	1	0	0
pH 1—3 hr	74	22	4	0
pH 1—6 hr	38	41	21	0
pH 1—29 hr	1	22	31	46
pH 3—1 hr	97	3	0	0
pH 3—3 hr	96	4	0	0
pH 3—6 hr	92	6	2	0
pH 3—29 hr	93	4	2	1
pH 5—1 hr	98	2	0	0
pH 5—3 hr	94	6	0	0
pH 5—6 hr	98	2	0	0
pH 5—29 hr	94	4	1	1
pH 7.4—1 hr	96	4	0	0
pH 7.4—3 hr	91	7	2	0
pH 7.4—6 hr	85	12	3	0
pH 7.4—29 hr	69	17	13	1

TAC: tri-acetyl-azacitidine; DAC: di-acetyl-azacitidine; MAC: mono-acetyl-azacitidine; ACT: azacitidine.