Table 3.
| Protein/domain with function | P. falciparum | P. knowlesi | P. vivax | P. yoelii |
|---|---|---|---|---|
| ATM (detection of DNA damage) | PF13_0072 (−2) PFD0690c (−2) | PKH_051590 (−2) | PVX_084530 (−5) | — |
|
| ||||
| p53 DBD (initiator of PCD) | PFE1120w (−2) PFE0325w (−1) | — | — | — |
|
| ||||
| MDM2/SWIB (negative regulation of p53 activity) | PF10_0167 (−1) | PKH_060130 (−1) | PVX_001730 (−2) | PY00201 (−1) |
|
| ||||
| CR6 (negative regulation of cell cycle) | MAL7P1.212 (−3) | PKH_101090 (−1) | — | — |
|
| ||||
| IAP (inhibitor of apoptosis) | PFE0985w (−2) | PKH_101280 (−3) | PVX_080265 (−4) | PY00703 (−1) |
|
| ||||
| Peptidase C14 (execution of apoptosis) | PF13_0289 (−22) PF14_0160 (−1) PF14_0363 (−1) | PKH_111640 (−25) PKH_133100 (−2) PKH_126800 (−1) | PVX_114725 (−22) PVX_085640 (−2) PVX_118575 (−1) | — PY04718 (−2) PY00663 (−1) |
Abbreviations: ATM: ataxia telangiectasia mutated; CR: cell regulator; DBD: DNA-binding domain; IAP: inhibitor of apoptosis protein; MDM2: murine double-minute 2; SWIB: swinged wings locus complex B; —: no orthologue detected.