Table 2.

Pharmacokinetic parameters for bupivacaine after administration of EXPAREL and lidocaine/epinephrine solution (4 : 4 dose ratio).

Time interval (min)a	Parameters for plasma bupivacaine
	(% change from bupivacaine control)
	AUC0−24 hr (hr·ng/mL)	C max⁡  (ng/mL)
0	2,240 ± 721	519 ± 230
5b	4,370 (+95%) (2,980–5,770)	5,730 (+1,000%) (3,690–7,770)
10	3,370 ± 1,980 (+50%)	865 ± 488 (+67%)
20	2,100 ± 445 (−6%)	412 ± 113 (−21%)
40	2,150 ± 410 (−4%)	422 ± 119 (−19%)

   ^a N = 3 per group (unless noted); ^b N = 2; one animal received 55% of the intended dose of EXPAREL. Data from this animal were not used in calculation of means.