Table 1.
32 full factorial design layout.
| Batch code | Variable levels in coded Form | Particle size (μm)* | Drug entrapment efficiency (%)* | t 80% (minutes)* | |
|---|---|---|---|---|---|
| X 1 | X 2 | ||||
| F1 | −1 | −1 | 221 | 55 | 283 |
| F2 | −1 | 0 | 212 | 49 | 281 |
| F3 | −1 | 1 | 206 | 47 | 264 |
| F4 | 0 | −1 | 251 | 64 | 284 |
| F5 | 0 | 0 | 245 | 59 | 287 |
| F6 | 0 | 1 | 234 | 57 | 300 |
| F7 | 1 | −1 | 290 | 70 | 571 |
| F8 | 1 | 0 | 277 | 67 | 547 |
| F9 | 1 | 1 | 269 | 64 | 456 |
|
| |||||
| Translation of coded levels in actual units | |||||
| Variables level | Low (−1) | Medium (0) | High (+1) | ||
|
| |||||
| Drug-to-polymer ratio (X 1) | 1 : 1 | 1 : 2 | 1 : 3 | ||
| Stirring speed (X 2) rpm | 800 | 1000 | 1200 | ||
*Average of three determination.