Table 3.
Analysis of variance (ANOVA) for all three responses(a).
| Entrapment efficiency (%) (Y 1) | Particle size (μm) (Y 2) | t 80% release (min) (Y 3) | ||||
|---|---|---|---|---|---|---|
| Source | F | P value | F | P value | F | P value |
| Model | 3.81 | .0801 | 1.08 | .4838 | 169.68 | .0001 |
| X1 | 1.60 | .2617 | 0.11 | .7556 | 326.82 | .0001 |
| X2 | 1.82 | .2349 | 0.70 | .4419 | 1.15 | .3325 |
| X1X2 | 0.21 | .6682 | 3.33 | .1277 | 13.97 | .0135 |
| X12 | 0.014 | .9103 | 0.61 | .4685 | 263.25 | .0001 |
| X22 | 1.21 | .3209 | 0.53 | .5011 | 0.77 | .4199 |
| X12X2 | 0.30 | .6061 | 0.19 | .6826 | 8.83 | .0311 |
| X1X22 | 2.51 | .1738 | 0.90 | .3857 | 3.18 | .1348 |
(a)Significant effect (P value <.5) of factors on individual responses are shown in bold; t 80% release: time of 80 percent of drug release; X 1: drug-to-polymer ratio; X 2: stirring speed.