Table 2.
Formulation and evaluation of 32 full factorial design batches.
| Batch code | X1 (HPMC grade) | X2 (% PVP K30 concentration) | Y1 (tensile strength kg/cm2) | Y2 (Q 1)(%) | Y3 (Q 9)(%) | Y4 (diffusion coefficient) |
|---|---|---|---|---|---|---|
| F1 | HPMC E15 LV | 0.5 | 0.38 | 9.780612 | 88.91582 | 1.043 |
| F2 | HPMC E15 LV | 1 | 0.46 | 11.31122 | 90.59949 | 1.001 |
| F3 | HPMC E15 LV | 1.5 | 0.63 | 12.22959 | 98.26531 | 0.983 |
| F4 | HPMC K100 | 0.5 | 0.45 | 13.30102 | 54.54082 | 0.665 |
| F5 | HPMC K100 | 1 | 0.58 | 13.91327 | 63.78827 | 0.746 |
| F6 | HPMC K100 | 1.5 | 0.92 | 18.96429 | 75.90561 | 0.641 |
| F7 | HPMC K4M | 0.5 | 0.53 | 7.331633 | 48.52041 | 0.959 |
| F8 | HPMC K4M | 1 | 0.84 | 8.862245 | 37.98469 | 0.656 |
| F9 | HPMC K4M | 1.5 | 0.95 | 9.627551 | 57.70408 | 0.853 |