Table 2.
Within-group comparisons of patient-reported improvements in the frequency of Raynaud's attacks and the difference of cytokine levels between pre- and post-treatment. P values were calculated using 2-tailed, paired t-tests. Data represents mean comparisons of changes in cytokines in those who had more than 50% reduction in frequency (number) of RP attacks compared to those who did not.
| Cytokine | Mean cytokine change | Difference | Std. error difference | P value | |
|---|---|---|---|---|---|
| Frequency of attacks improved by ≥50% (n = 7) | Frequency of attacks improved by <50% (n = 6) | ||||
| sE-Selectin | 5843.8 | −3473.3 | 9317.1 | 4203.1 | 0.049 |
| sVCAM-1 | 134550.6 | −14819.9 | 149370.5 | 122138.5 | 0.247 |
| sICAM-1 | 8861.6 | −13292.5 | 22154.1 | 17813.4 | 0.239 |
| MMP-9 | 68574.0 | −104997.8 | 173571.8 | 57260.1 | 0.011 |
| tPAI-1 | −188.4 | −10086.1 | 9897.7 | 7392.6 | 0.208 |
| IL-4 | −0.2 | 0.0 | −0.2 | 0.2 | 0.356 |
| IL-6 | −2.6 | 0.1 | −2.7 | 2.9 | 0.387 |
| IL-8 | −0.4 | −1.1 | 0.7 | 1.9 | 0.726 |
| IL-10 | 0.0 | 0.0 | |||
| IL-12p70 | 0.3 | 0.1 | 0.3 | 0.3 | 0.416 |
| IL-17 | 0.0 | −0.5 | 0.5 | 0.5 | 0.363 |
| Eotaxin | −4.6 | 0.6 | −5.2 | 9.4 | 0.588 |
| Basic FGF | 1.0 | 3.4 | −2.5 | 2.9 | 0.408 |
| G-CSF | 15.0 | −12.1 | 27.0 | 10.0 | 0.020 |
| IFN-γ | −13.6 | 0.6 | −14.1 | 21.8 | 0.531 |
| IP-10 | 110.1 | 78.9 | 31.2 | 106.8 | 0.776 |
| MCP-1 | −12.4 | −3.1 | −9.3 | 20.2 | 0.654 |
| MIP-1α | −0.4 | 0.3 | −0.7 | 0.5 | 0.199 |
| MIP-1β | 7.1 | −3.5 | 10.6 | 5.5 | 0.082 |
| PDGF-BB | −133.4 | −244.1 | 110.7 | 309.2 | 0.727 |
| TNF- α | −1.0 | 2.2 | −3.2 | 3.1 | 0.341 |
| VEGF | 7.3 | −11.5 | 18.8 | 6.3 | 0.012 |
| TGF-β1 | −2.4 | −4.1 | 1.7 | 2.9 | 0.565 |