Figure 2.

A clinical management guideline using cerebral oxygenation from the brain to improve the clinical care of extremely preterm infants during the first 48 h after birth. Many aspects of neonatal intensive care are involved. Although the guideline reflects a large body of knowledge of pathophysiology in the newborn brain, some of the interventions have not been shown directly to improve cerebral oxygenation. The guideline was developed during the planning of a randomized controlled trial by a European Academic Consortium with partners from Copenhagen, Utrecht, Leuven, Madrid, Zurich, Uppsala, Milan, Graz, Cambridge, Witten/Herdecke, Lyon and Cork. CPAP, continuous positive airway pressure; GA, gestational age; HB, haemoglobin; PDA, patent ductus arteriosus; PEEP, positive end-expiratory pressure.