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. 2011 Nov 28;369(1955):4440–4451. doi: 10.1098/rsta.2011.0261

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Figure 6. — Simulated StO₂ in a two-layer geometry as a function of brain SO₂. The SO₂ in the skin/skull layer was fixed at 70%. All results deviate from the true brain value. The discrepancy is expected for two main reasons. The first is that the spatially resolved spectroscopy (SRS)-based StO₂ algorithm ignores the effect of water. The second reason is that the SRS algorithm is based on the assumption of a homogeneous semi-infinite half-space geometry. All designs are responsive to changes in brain SO₂. Designs 1 and 2 underread greatly, whereas the designs with larger source–detector distance all produced similar results. (Online version in colour.)