Figure 8.

Comparison of simulation results with experiments. (a) H³-labelled cells on the surface of EMT6 spheroids at 24 h (Dorie et al. 1982). (b) Cells remain at the surface in the simulations as observed experimentally in (a). (c) Internalized microspheres in spheroids at 48 h (Dorie et al. 1982). (d) Simulation results showing internalized discs. (e–f) Simulation results showing frequency of distance from the edge for (e) labelled cells at 0, 54, 114, 167 h and (f) discs (microspheres) at 0, 84, 198, 270 h. In the simulations, the labelled cells and discs were placed on the surface initially. ((a,c) Reprinted from Dorie et al. (1982), with permission.)