Table 1. Candidate ASD Genes based on Mouse Phenomics.
Genes from ABBA or MouseNET analysis that have orthologous with human genes implicated in ASD by CNV analysis and/or genes associated with an abnormal neurological phenotype. The first three columns represent ASD candidate genes identified by different stages of our analysis and the fourth column represents genes associated with an abnormal neurological phenotype in mice. The last column represents human orthologs implicated in ASD by CNV analysis as described in Pinto et al [8]
| Gene symbol |
MGI ID | Phenome Map |
MouseNET | ABBA | Neurological phenotype (mice) |
CNV implicated ASD |
|---|---|---|---|---|---|---|
| Anks1b | MGI:1924781 | x | x | |||
| Camk4 | MGI:88258 | x | x | x | ||
| Cask | MGI:1309489 | x | x | x | ||
| Chrna3 | MGI:87887 | x | x | x | ||
| Chrnb4 | MGI:87892 | x | x | x | ||
| Dsc3 | MGI:1194993 | x | x | |||
| Fgfr3 | MGI:95524 | x | x | x | ||
| Ghr | MGI:95708 | x | x | x | ||
| Plcb4 | MGI:107464 | x | x | x | x | |
| Thrb | MGI:98743 | x | x | x | ||
| Unc5c | MGI:1095412 | x | x | x | x | x |
| Amph | MGI:103574 | x | x | |||
| Apc | MGI:88039 | x | x | |||
| Cacna1a | MGI:109482 | x | x | x | x | |
| Cadps | MGI:1350922 | x | x | |||
| En1 | MGI:95389 | x | x | x | ||
| Foxp2 | MGI:2148705 | x | x | x | ||
| Gria2 | MGI:95809 | x | x | x | x | |
| Grin1 | MGI:95819 | x | x | x | ||
| Grin3b | MGI:2150393 | x | x | x | ||
| L1cam | MGI:96721 | x | x | x | ||
| Met | MGI:96969 | x | x | x | ||
| Mll1 | MGI:96995 | x | x | |||
| Pax3 | MGI:97487 | x | x | x | ||
| Pkd1 | MGI:97603 | x | x | x | ||
| Rora | MGI:104661 | x | x | x | ||
| Slc6a4 | MGI:96285 | x | x |