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. Author manuscript; available in PMC: 2012 Jan 23.
Published in final edited form as: Clin Cancer Res. 2011 Jan 1;17(1):122–133. doi: 10.1158/1078-0432.CCR-10-0253

Figure 1. HSP-90 inhibition induces degradation of MET and inhibition of proliferation in tumor cells with MET amplification.

Figure 1

(A) Tumor cells were treated with SNX-2112 for 24 h as indicated, followed by Western Blot analysis. (B) Comparative kinetics of HSP-90 and selective MET kinase inhibition in GTL-16 gastric cancer cells. Cells were either treated with 1000 nM SNX-2112 or 400 nM PHA-665752 as indicated, followed by Western Blot analysis. (C) Cells were treated for 24 h as indicated, followed by cell proliferation analysis. Data are depicted as mean ± SE.