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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Future Oncol. 2011 Dec;7(12):1457–1473. doi: 10.2217/fon.11.121

Figure 2. Adipose-derived stem cells stimulated with VEGF-C demonstrate early expression of lymphatic endothelial cell markers and loss of stem cell markers.

Figure 2

Podoplanin staining of tissues harvested from various groups after Matrigel implantation. (A) Relative mRNA expression by adipose-derived stem cells for Prox-1, LYVE-1, VEGF-C, VEGF-A and VEGFR-3 following 48-h exposure to VEGF-C in vitro. Baseline expression of these markers is set to one in unstimulated cells (*p < 0.05, **p < 0.01 and ***p < 0.001). (B) Flow cytometry analysis of isolated adipose-derived stem cells demonstrating expression of stem cell markers (Sca1, CD29) and endothelial and lymphatic endothelial cell markers (CD31, VEGFR3) before (upper panel) and after 48-h stimulation with VEGF-C (lower panel) in vitro.