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Mean difference in change in HbA1c of metformin treatment versus comparator (boxes) and pooled estimates (diamonds) calculated by the random-effects DerSimonian and Laird method, stratified by metformin monotherapy and metformin added to an oral antidiabetes medication. Horizontal bars and diamond widths denote 95% CIs, and box sizes indicate relative weight in the analysis. (A high-quality color representation of this figure is available in the online issue.)
