TABLE 1.

Agonist and modulator evoked response characteristics

The values in square brackets indicate the number of replicate oocytes for each measurement. Fits to the Hill equation for experiments with ACh + 10 μM Mor or ACh + 10 μM Oxa in all cases, except for α3L107Hβ2, which was ACh + 50 μM Oxa.

Subtype	ACh Response		Modulation Response
			Mor			Oxa
	EC50	nH [n]	EC50	nH	Emax [n]	EC50	nH	Emax [n]
	μM		μM			μM
α3β2	66 ± 9	0.75 ± 0.07 [5–11]	10 ± 6	1.37 ± 0.80	2.64 ± 0.29 [5]	9 ± 1	1.54 ± 0.25	2.27 ± 0.06 [3]
α4β2	21 ± 4	0.59 ± 0.06 [6–12]	41 ± 9	0.49 ± 0.06	1.06 ± 0.14 [3–10]	370 ± 65	1.15 ± 0.36	0.85 ± 0.13 [5]
α3W53Aβ2	42 ± 2	1.08 ± 0.06 [6–10]	20 ± 3	1.28 ± 0.25	1.12 ± 0.04 [4]	47 ± 7	1.54 ± 0.24	1.16 ± 0.04 [4]
α3β2W149A	40 ± 6	0.99 ± 0.12 [5]	44 ± 6	1.38 ± 0.19	0.86 ± 0.03 [5]	110 ± 3	1.44 ± 0.06	0.90 ± 0.01 [6]
α3K109Fβ2	86 ± 14	0.66 ± 0.07 [12]	7 ± 2	1.13 ± 0.25	4.55 ± 0.22 [7]	13 ± 3	1.45 ± 0.46	3.53 ± 0.19 [5]
α3L107Cβ2	62 ± 7	0.71 ± 0.06 [6–9]	4.9 ± 0.9	1.33 ± 0.33	3.49 ± 0.15 [3]	13 ± 2	1.11 ± 0.13	1.56 ± 0.04 [7]
α3L107Hβ2	27 ± 4	1.02 ± 0.13 [17]	18 ± 2	1.15 ± 0.13	1.15 ± 0.03 [9]	106 ± 9	2.21 ± 0.78	1.04 ± 0.04 [8]
α3E113Rβ2	40 ± 5	1.01 ± 0.12 [10]	10 ± 6	1.53 ± 0.95	2.03 ± 0.22 [5]	80 ± 8	1.59 ± 0.24	0.97 ± 0.03 [5]
α3T115Cβ2	120 ± 20	0.71 ± 0.07 [9]	5 ± 2	1.48 ± 0.79	2.84 ± 0.22 [5]	9 ± 2	0.96 ± 0.21	1.62 ± 0.08 [4]
α3T115Qβ2	280 ± 40	0.96 ± 0.12 [5–10]	2.2 ± 0.6	1.27 ± 0.49	5.14 ± 0.29 [5]	18 ± 3	2.23 ± 0.75	5.03 ± 0.23 [5]
α3I117Tβ2	16 ± 2	0.93 ± 0.08 [15]	37 ± 12	0.85 ± 0.19	0.97 ± 0.07 [8]	50 ± 7	1.24 ± 0.17	0.95 ± 0.03 [7]
α3I57Eβ2	110 ± 10	0.83 ± 0.05 [5–13]	6 ± 3	0.57 ± 0.23	1.70 ± 0.17 [7]	6 ± 2	0.90 ± 0.25	1.15 ± 0.06 [6]
α3/α4[3]β2	22 ± 4	0.93 ± 0.13 [9]	26 ± 8	1.06 ± 0.32	0.94 ± 0.07 [4]	59 ± 18	1.50 ± 0.53	0.47 ± 0.04 [5]
α3/α4[5]β2	20 ± 3	1.15 ± 0.19 [10]	18 ± 5	1.31 ± 0.43	0.93 ± 0.05 [4]	94 ± 13	0.95 ± 0.11	0.88 ± 0.03 [6]