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. 2012 Feb;81(2):113–119. doi: 10.1124/mol.111.076141

Fig. 1.

Fig. 1.

In vivo administration of lurasidone induces a significant enhancement of NMDAR-EPSC. A, dot plots showing the amplitude of NMDAR-EPSC in PFC pyramidal neurons from rats injected with saline, lurasidone (0.1 mg/kg s.c.), or clozapine (5 mg/kg s.c.). Inset, representative NMDAR-EPSC. Scale bar, 50 pA, 100 ms. B, summarized input-output curves of NMDAR-EPSC in response to a series of stimulation intensity in saline- versus lurasidone-injected rats. *, p < 0.001, Kruskal-Wallis test. C, plot of normalized NMDAR-EPSC showing the effect of ifenprodil (an NR2B antagonist, 5 μM) in PFC neurons from saline- versus lurasidone-injected rats. D, bar graphs summarizing the percentage reduction of NMDAR-EPSC amplitude by ifenprodil in saline- versus lurasidone-injected rats.