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. 2012 Feb;340(2):404–421. doi: 10.1124/jpet.111.187443

Fig. 1.

Fig. 1.

VU0364770 is a potent and effective PAM of mGlu4. A and B, VU0346770 exhibits a potency of 1.1 ± 0.2 μM at human mGlu4 in the presence of an EC20 concentration of glutamate (A) and shifts the glutamate concentration-response curve 31.4 ± 4.0-fold to the left (B). C and D, VU0364770 exhibits a potency of 290 ± 80 nM at rat mGlu4 (C) and induces an 18.1 ± 1.7-fold left shift of the glutamate concentration-response curve (D). Data were previously presented in tabular form (Engers et al., 2009).