Fig. 3.
The mGlu4 PAM VU0364770 produces a dose-dependent reversal of haloperidol (0.75 mg/kg i.p.)-induced catalepsy in rats. A, for comparison, the effects of VU0364770 were compared with a top dose of a previously published A2A antagonist from Neurocrine. B, in contrast, the structural analog VU0364772 (inactive at mGlu4in vitro) had no effect across the dose range tested on haloperidol-induced catalepsy. Catalepsy was measured as the latency to withdraw the forepaws from a horizontal bar with a cutoff of 30 s. Bar graphs represent the means ± S.E.M. of 10 to 12 rats/treatment group. **, p < 0.05 versus the vehicle control group by Dunnett's test. VEH, vehicle.