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VU0364770 exhibits anticataleptic efficacy up to 2 h after administration. VU0364770 exhibited a reversal of haloperidol-induced catalepsy for up to 2 h after pretreatment. Catalepsy was measured as the latency to withdraw the forepaws from a horizontal bar with a cutoff of 30 s. Bar graphs represent the means ± S.E.M. of 10 to 12 rats/treatment group. ***, P < 0.001 versus the vehicle control group by Dunnett's test.
