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. 2012 Feb;340(2):404–421. doi: 10.1124/jpet.111.187443

Fig. 7.

Fig. 7.

VU0364770 produces a reversal of forelimb asymmetry induced by unilateral 6-OHDA lesion of the median forebrain bundle in rats alone or in combination with an inactive dose of l-DOPA. A, the dose-dependent reversal of forelimb asymmetry (as measured by the forelimb asymmetry index score) by l-DOPA. B, the moderate improvement of forelimb asymmetry by VU0364770 (100 mg/kg s.c.) or robust reversal in combination with l-DOPA (1.5 mg/kg p.o.). Each bar graph represents the means ± S.E.M. of 5 to 15 (A) and 9 to 15 (B) rats/treatment group. *, p < 0.05; **, P < 0.01 versus the vehicle control group by Dunnett's test.